It used to be easy to reverse mouse wheel scrolling direction. I’m talking mouse wheel, not touchpad:

Now it takes a registry hack.

HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\HID

In there, find the right key name (eg: “VID_046D&PID_C52F&MI_00“) and under that, Device Parameters\FlipFlopWheel set from 0 to 1.

Reference: ilovefreesoftware.com :  How To Reverse Mouse Wheel Scroll Direction In Windows 10

• http://www.ilovefreesoftware.com/18/tutorial/reverse-mouse-wheel-scroll-direction-windows-10.html