It used to be easy to reverse mouse wheel scrolling direction. I’m talking mouse wheel, not touchpad:
Now it takes a registry hack.
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\HID
In there, find the right key name (eg: “VID_046D&PID_C52F&MI_00
“) and under that, Device Parameters\FlipFlopWheel
set from 0 to 1.
Reference: ilovefreesoftware.com : How To Reverse Mouse Wheel Scroll Direction In Windows 10